6-(Piperidinyl)-2,4-pyrimidinediamine-3-oxide (Minoxidil (INN)) and its salts

22

Avoid

CAS Number: 38304-91-5

About 6-(Piperidinyl)-2,4-pyrimidinediamine-3-oxide (Minoxidil (INN)) and its salts

A potent vasodilator drug listed in EU Annex III for restricted hair-growth cosmetic use, carrying a pubchem_safety_score of 8 reflecting its pharmaceutical nature.

Detailed Analysis

Minoxidil is listed in EU Annex III/1 (hair growth substances) with specific restrictions on its use in cosmetic products intended for hair growth stimulation. Despite its potent pharmacological vasodilatory action, it is permitted at low concentrations in scalp treatments in some EU member states, though it remains a prescription-drug-level ingredient with systemic cardiovascular risk if improperly used. Its pubchem_safety_score of 8 confirms its drug-like hazard profile.

Skin Benefits

  • ✓ Promotes hair growth by vasodilation of scalp blood vessels (pharmaceutical use)

Known Concerns

  • ⚠ Drug-level potency — cardiovascular effects with systemic absorption
  • ⚠ Restricted under EU Annex III for hair growth products
  • ⚠ Not for general cosmetic use

Safety Score

22

Avoid

Based on EU regulatory data, published safety research, and ingredient function analysis.

References

🏛

EU CosIng Database

European Commission cosmetic ingredient registry

Check your products for 6-(Piperidinyl)-2,4-pyrimidinediamine-3-oxide (Minoxidil (INN)) and its salts

Scan any cosmetic product to see if it contains this ingredient and get a full safety breakdown.

Download LuxSense

This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for skin concerns or allergies.