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1,4-Dihydroxybenzene (Hydroquinone), with the exception of entry 14 in Annex III

CAS 123-31-9
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A cosmetic ingredient. Exercise caution due to limited available safety data.

1,4-Dihydroxybenzene (Hydroquinone) is banned in cosmetic products under EU Annex II of Regulation (EC) No 1223/2009 (entry 1339). It is classified as carcinogenic (H351), mutagenic (H341) and a skin sensitiser (H317) under the CLP Regulation. Its use is strictly limited to artificial nail systems under highly controlled conditions. Any cosmetic product containing hydroquinone is non-compliant with EU law.

Known concerns

  • EU Annex II banned substance (entry 1339)
  • Carcinogenic (H351) and mutagenic (H341)
  • Severe skin sensitiser (H317)
  • Ochronosis with prolonged use
  • Eye and organ toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Check your shelf

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.