1-Dimethylaminomethyl-1-methylpropyl benzoate (amylocaine) and its salts
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A local anesthetic ester-type compound related to cocaine, historically used as a dental anesthetic. The amylocaine structure raises significant safety concerns for cosmetic use, with limited modern safety data.
1-Dimethylaminomethyl-1-methylpropyl benzoate (amylocaine) is a ester-type local anesthetic structurally related to cocaine. The ester linkage is susceptible to hydrolysis, potentially releasing the toxic alcohol component. It is not listed in EU Annex II (banned substances) or Annex III (restricted substances) of the Cosmetics Regulation, suggesting permitted cosmetic use, though this likely reflects absence of cosmetic applications rather than established safety. Esterase activity in skin can release degradation products.
Skin benefits
- Historical anesthetic use
Known concerns
- Ester-type anesthetic with potential for hydrolysis and degradation
- Limited modern toxicological and sensitization data
- Structural similarity to cocaine-class anesthetics raises concerns
- Potential for systemic absorption
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.