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2-Phenylindan-1,3-dione (Phenindione (INN))

CAS 83-12-5
25

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

2-Phenylindan-1,3-dione (Phenindione (INN)) is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

2-Phenylindan-1,3-dione (Phenindione) is an indanedione anticoagulant drug (vitamin K antagonist) with pharmacological activity that makes it completely unsuitable for cosmetic application. It carries H301 (acute toxicity) and H317 (skin sensitizer) classifications. Its primary use is as a rodenticide and pharmaceutical anticoagulant, not cosmetics. The compound is not listed in EU cosmetic regulation Annexes but is clearly contraindicated by its pharmacological nature and toxicity profile.

Known concerns

  • Acute oral toxicity (H301)
  • Skin sensitizer (H317)
  • Pharmacological drug activity (anticoagulant)
  • Not suitable for cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.