Banned Substance
4-nitrosomorpholine
Safety score · 0–100
Not Rated
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
An N-nitrosamine formed when morpholine meets nitrite. Potent animal carcinogen, classified under EU CLP Cat 1B, prohibited in cosmetics.
N-Nitrosomorpholine (4-nitrosomorpholine, CAS 59-89-2) is an N-nitrosamine formed by reaction of morpholine (a common industrial amine, including in some rubber and corrosion-inhibitor chemistries) with nitrosating species such as nitrites. In laboratory animal studies it is a potent hepatocarcinogen across multiple species and routes. IARC classifies it as Group 2B (possibly carcinogenic to humans), and EU CLP classifies it as a Category 1B carcinogen (H350). As with the wider N-nitrosamine class, it is prohibited in cosmetic products under EU Regulation (EC) No 1223/2009 Annex II, and formulators must avoid combinations of secondary amines with nitrosating agents that could form nitrosamines in-product. No intentional cosmetic use exists.
Skin benefits
- No legitimate cosmetic use — N-nitrosamine carcinogen
Known concerns
- Potent animal hepatocarcinogen
- IARC Group 2B
- EU CLP Cat 1B carcinogen
- Can form in-situ from morpholine + nitrite
- EU Annex II cosmetic ban
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related banned substances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.