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Allyl isothiocyanate

CAS 57-06-7
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A severe skin irritant and sensitizer derived from mustard seeds that causes burns and allergic reactions, restricted to trace levels in EU cosmetics.

Allyl isothiocyanate (AITC, mustard oil) is an organosulfur compound responsible for the pungency of mustard, horseradish, and wasabi. It is classified H226 (flammable liquid), H301/H310/H330 (acute toxicity), H315 (skin irritation), H317 (skin sensitization), H319 (eye irritation), H400/H410 (aquatic toxicity), H302/H373 (toxicity), and H361 (reproductive toxicity). EU Annex III restricts AITC at ≥0.1% in cosmetic products. It is a potent skin sensitizer and irritant despite its natural origin.

Known concerns

  • Potent skin sensitizer H317
  • Severe skin irritant H315
  • Acute toxicity H301/H310/H330
  • Eye irritation H319
  • Flammable H226
  • Restricted to ≤0.1% in EU cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.