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ALLYLANISOLE

CAS 140-67-0
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A naturally occurring phenylpropenoid compound (estragole) found in tarragon and basil, classified as a suspected human carcinogen by IARC with EU restrictions on certain food uses.

Estragole (trans-anethole derivative, 4-allylanisole) is a phenylpropenoid ether occurring naturally in essential oils of tarragon, basil, and fennel. The IARC has classified estragole as a Group 2A probable human carcinogen based on rodent studies, and the EU SCCS has assessed it as raising concern for genotoxic carcinogenicity. While not currently on EU Annex II for cosmetics, it is restricted in food uses and requires careful cosmetic formulation consideration. PubChem safety score of 40 reflects these concerns.

Skin benefits

  • Natural fragrance compound with herbal scent profile

Known concerns

  • IARC Group 2A probable human carcinogen
  • EU SCCS concern for genotoxic carcinogenicity
  • EU restricted in food uses — applicable risk for cosmetics
  • Recommended for restriction in cosmetic formulations

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.