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Ammonium fluoride

CAS 12125-01-8
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An inorganic fluoride source used in oral care products at up to 0.15% F concentration, restricted in EU to prevent excessive fluoride exposure and fluorosis risk.

Ammonium fluoride (CAS 12125-01-8) functions as a fluoride source in toothpaste and mouthwash formulations for caries prevention. EU Regulation 1223/2009 Annex III limits the total fluoride concentration to 0.15% (1500 ppm) when mixed with other permitted fluorine compounds. Excessive fluoride exposure during tooth development can cause dental fluorosis, and chronic high exposure may lead to skeletal fluorosis. The restriction ensures consumer safety while maintaining effective anticaries benefits at approved concentrations.

Skin benefits

  • Provides fluoride for caries prevention in oral care
  • Strengthens tooth enamel at approved concentrations
  • Reduces demineralization of dental tissues

Known concerns

  • Maximum 0.15% total fluoride in EU oral care products
  • Risk of dental fluorosis in children with excessive use
  • Skeletal fluorosis risk from chronic overexposure
  • Must not exceed total F limit when combined with other fluorides

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.