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BIFONAZOLE

CAS 60628-96-8
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An imidazole antifungal agent originally developed as a pharmaceutical for topical fungal infections that is not approved as a cosmetic preservative or active ingredient in the EU, with limited safety data for cosmetic formulation.

Bifonazole is a broad-spectrum imidazole antifungal used in pharmaceutical creams for the treatment of tinea and candidiasis. While imidazole antifungals are generally well-tolerated in topical pharmaceuticals, bifonazole specifically is not listed in EU CosIng for cosmetic use. The imidazole ring can act as a histamine releaser and may cause local skin reactions.

Skin benefits

  • Pharmaceutical: broad-spectrum antifungal useful for treating fungal skin infections

Known concerns

  • Not listed in EU CosIng for cosmetic use
  • Imidazole ring may cause histamine release and local skin reactions
  • Pharmaceutical-grade active not appropriate for cosmetic formulations without safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.