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BIS-HEMA IPDI

CAS -
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A methacrylate-functional urethane oligomer that is a skin sensitiser due to its HEMA content and methacrylate monomer component, with very limited cosmetic application due to regulatory restrictions.

Bis-HEMA IPDI is a urethane di-methacrylate oligomer formed from isophorone diisocyanate (IPDI) and hydroxyethyl methacrylate (HEMA). HEMA and related methacrylate monomers are known skin sensitisers and are subject to regulatory restrictions in cosmetic nail and dental products in the EU. While used extensively in nail gel and dental restorative formulations, this type of ingredient has very limited use in conventional skin or hair care cosmetics. EU Annex III entry 1349 restricts certain methacrylate monomers in nail products. The ingredient carries hazard profile dominated by its methacrylate functionality.

Known concerns

  • Contains HEMA (hydroxyethyl methacrylate) - sensitisation risk
  • Acrylate/methacrylate monomer - potential for skin sensitisation
  • Industrial-use monomer not typically in cosmetic formulations
  • CMR concerns noted in some regulatory reviews

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.