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Antioxidant

BIS-HYDROXYETHYL TOCOPHERYLSUCCINOYLAMIDO HYDROXYPROPANE

78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A water-dispersible vitamin E derivative — delivers tocopherol antioxidant activity with better formulation compatibility.

Bis-Hydroxyethyl Tocopherylsuccinoylamido Hydroxypropane is a synthetic derivative of alpha-tocopherol (vitamin E), conjugated via a succinate-amido-propane linker to bis-hydroxyethyl groups that confer water-dispersibility. In cosmetics it functions as an antioxidant and skin-conditioning agent, intended to provide vitamin-E-like oxidative protection in formulations where lipophilic tocopherol would be difficult to use. Mechanistically, it requires enzymatic hydrolysis in skin to liberate active tocopherol, analogous to tocopheryl acetate. Public toxicology on this specific derivative is limited to supplier dossiers, so CIR/SCCS anchoring is indirect, relying on the well-documented safety of the parent vitamin-E family. Succinate/succinoylamido esters have been used safely in cosmetic and pharmaceutical contexts; no endocrine or genotoxic flags have surfaced.

Skin benefits

  • Antioxidant vitamin-E delivery
  • Water-dispersible formulation advantage
  • Skin conditioning

Known concerns

  • Proprietary ester — limited dedicated toxicology
  • Requires skin hydrolysis for activity
  • Potential mild irritation at elevated %

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.