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BUTYROLACTONE

CAS 96-48-0
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Gamma-butyrolactone (GBL), a cyclic ester classified as a CMR substance (Repr. 1B, H360) and restricted under EU Annex II/1584, with multiple severe hazard classifications.

Butyrolactone (gamma-butyrolactone, GBL) is classified as a CMR substance (Reproductive toxicity, Repr. 1B, H360) under CLP Regulation 1272/2008. It appears in EU Cosmetics Regulation 1223/2009 Annex II/1584 as a prohibited substance for cosmetic use. Additionally, it carries hazard statements H302, H315, H318, H319, H331 (acute inhalation toxicity), H336 (CNS effects), and H371 (organ effects). Its use in cosmetics is strictly prohibited in the EU.

Skin benefits

  • Not applicable; prohibited ingredient in EU cosmetics

Known concerns

  • EU Annex II/1584 prohibits use in cosmetic products
  • CMR substance: Reproductive toxicity H360D
  • Acute inhalation toxicity H331
  • Serious eye damage H318
  • Skin irritation H315
  • CNS effects H336

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.