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Skin Conditioning

CAPSAICINYL SUCCINOYL TRIPEPTIDE-35

62

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A capsaicin-peptide hybrid used for warming and microcirculation effects. Capsaicin origin keeps it in caution territory despite being bound to a peptide.

Capsaicinyl succinoyl tripeptide-35 is a synthetic conjugate linking a capsaicin moiety (the pungent principle of chili peppers) via a succinoyl spacer to a short tripeptide. It is marketed for warming sensations, microcirculation support, and scalp-stimulating hair products. The peptide conjugation is intended to modulate release and reduce direct capsaicin irritation. Free capsaicin is a well-characterized TRPV1 agonist and skin irritant; the safety profile of this specific conjugate is proprietary and supplier-supplied rather than established through SCCS/CIR review. No standardized regulatory category; caution advised on broken or sensitive skin.

Function

ANTIOXIDANT, SKIN PROTECTING

Skin benefits

  • Marketed for warming/microcirculation effect in scalp and body products
  • Peptide-conjugated delivery may reduce capsaicin irritation
  • Low use levels minimize systemic exposure

Known concerns

  • Capsaicin moiety is a known irritant and TRPV1 agonist
  • Limited independent toxicology data on the peptide conjugate
  • Potential for burning or stinging on sensitive skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.