Skin Conditioning
CAPSAICINYL SUCCINOYL TRIPEPTIDE-35
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A capsaicin-peptide hybrid used for warming and microcirculation effects. Capsaicin origin keeps it in caution territory despite being bound to a peptide.
Capsaicinyl succinoyl tripeptide-35 is a synthetic conjugate linking a capsaicin moiety (the pungent principle of chili peppers) via a succinoyl spacer to a short tripeptide. It is marketed for warming sensations, microcirculation support, and scalp-stimulating hair products. The peptide conjugation is intended to modulate release and reduce direct capsaicin irritation. Free capsaicin is a well-characterized TRPV1 agonist and skin irritant; the safety profile of this specific conjugate is proprietary and supplier-supplied rather than established through SCCS/CIR review. No standardized regulatory category; caution advised on broken or sensitive skin.
Function
Skin benefits
- Marketed for warming/microcirculation effect in scalp and body products
- Peptide-conjugated delivery may reduce capsaicin irritation
- Low use levels minimize systemic exposure
Known concerns
- Capsaicin moiety is a known irritant and TRPV1 agonist
- Limited independent toxicology data on the peptide conjugate
- Potential for burning or stinging on sensitive skin
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.