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CHAMAZULENE

CAS 529-05-5
85

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Chamazulene is a cosmetic ingredient used in product formulations. Note: classified as harmful to aquatic environments. Exercise caution due to limited available safety data.

Chamazulene (also called guaiazulene) is a sesquiterpene azulene derived from the essential oils of chamomile (Matricaria chamomilla) and blue tansy (Tanacetum annuum). It is used in cosmetics for its potent anti-inflammatory, antioxidant, and skin-soothing properties. Chamazulene is not listed on any EU restriction Annexes; it is considered safe at concentrations up to 0.1% in cosmetic formulations. SCCS notes high cosmetic acceptance and low systemic toxicity. The ingredient is permitted in all cosmetic product types including leave-on and is a popular natural-derived active for sensitive skin formulations.

Skin benefits

  • Potent anti-inflammatory - reduces skin redness and irritation
  • Antioxidant - protects skin from free radical damage
  • Soothing and calming for sensitive or reactive skin
  • May support wound healing and post-procedure skin recovery

Known concerns

  • May cause discoloration of skin (blue staining)
  • Natural ingredient - potential for batch-to-batch variation in allergen content
  • Related to Azulene - those with Compositae allergy should exercise caution

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.