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Chlorpropamide (INN)

CAS 94-20-2
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Chlorpropamide (inn) is a cosmetic ingredient. Raw material is classified as a suspected carcinogen. Exercise caution due to limited available safety data.

Chlorpropamide (CAS 94-20-2) is a first-generation sulfonylurea used orally for type 2 diabetes management. EU Regulation 1223/2009 Annex III restricts its use to concentrations below 0.1% as a constituent of substances or mixtures. The compound functions as an insulin secretagogue, lowering blood glucose levels. Cosmetic use could lead to unintended systemic absorption and pharmacological effects including severe hypoglycemia, particularly dangerous in diabetic patients. The compound carries hazard statements H312+H332 (harmful in contact with skin or if inhaled) and H351 (suspected of causing cancer).

Known concerns

  • Restricted to <0.1% in EU mixtures
  • Hypoglycemia risk from systemic absorption
  • Phototoxicity concern
  • Suspected carcinogen (H351)
  • Potential drug interactions with oral hypoglycemics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.