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Dihydrotachysterol (INN)

CAS 67-96-9
40

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A vitamin D analog used in anti-aging cosmetics but regulated as a drug substance in many jurisdictions due to its potency.

Dihydrotachysterol (DHT; 9,10-secoergosta-5,7,22-trien-3-beta-ol) is a reduced form of tachysterol and a vitamin D analog. It is used in cosmetic formulations for its effects on skin cell differentiation and barrier function. However, it is regulated as a drug substance in the EU (used orally for hypocalcemia) and its use in cosmetics is restricted. Overuse can lead to hypervitaminosis D, making concentration control critical.

Skin benefits

  • Supports skin cell differentiation and turnover
  • May enhance barrier function at low concentrations

Known concerns

  • Vitamin D analog with drug classification in EU
  • Risk of vitamin D toxicity if concentrations are not controlled
  • Restricted substance requiring careful safety assessment
  • Potentially significant systemic effects from percutaneous absorption

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.