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DL-Phenylephrine hydrochloride

CAS 20368-45-0
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Dl-phenylephrine Hydrochloride is a cosmetic ingredient. Exercise caution due to limited available safety data.

Phenylephrine is a synthetic alpha-adrenergic agonist widely used as a nasal and ocular decongestant in pharmaceutical preparations. Its hydrochloride salt shows irritant properties (H302, H312, H315, H319, H332) and presents cardiovascular risks with systemic absorption. It is a prescription-free medicine in some EU countries but remains a pharmacological agent not approved as a cosmetic functional ingredient.

Known concerns

  • Skin and eye irritation (H315, H319)
  • Acute oral and dermal toxicity (H302, H312)
  • Respiratory irritation (H332)
  • Cardiovascular effects with systemic absorption

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.