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FOENICULUM VULGARE SEED

CAS 92623-75-1
70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Alicing seed from fennel — provides antioxidant and anti-inflammatory benefits through anethole and fenchone, though trans-anethole raises some endocrine-activity questions at high doses.

Foeniculum vulgare seed contains essential oil components dominated by trans-anethole (60-90%), with fenchone, estragole, and limonene as secondary constituents. The fixed oil fraction contains fatty acids including petroselinic acid. Anethole has demonstrated antioxidant and anti-inflammatory activity in vitro, though trans-anethole has also been studied for potential endocrine-modulating effects at high systemic doses (relevant primarily for food/internal use). Topical cosmetic use at low concentrations presents minimal risk; however, it should be used with caution during pregnancy due to the estragole content and the traditional emmenagogue associations of fennel essential oil.

Skin benefits

  • Antioxidant protection
  • Anti-inflammatory activity
  • Mild astringent
  • Skin conditioning

Known concerns

  • Trans-anethole studied for potential endocrine activity at high systemic doses
  • Estragole is a EU-regulated substance due to genotoxicity concerns at high doses
  • Sensitization possible in Apiaceae-sensitive individuals
  • Traditional use warnings for pregnancy — caution advised

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.