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pH Adjuster

GLYCINE HCL

CAS 6000-43-7
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

The hydrochloride salt of glycine — used as a pH buffer but can cause skin burns and serious eye damage at high concentrations.

Glycine HCl is the hydrochloride salt of the amino acid glycine, used as a buffering agent in cosmetic formulations. GHS data shows H314 (severe skin burns, 33.3%), H318 (serious eye damage, 44.4%), H315 (skin irritation), and H335 (respiratory irritation). The corrosive nature at high concentrations is due to its acidic pH. In diluted formulations it acts as a mild buffer, but the raw material's hazard profile is concerning.

Function

BUFFERING

Skin benefits

  • pH buffering

Known concerns

  • Severe skin burns at high concentration (H314)
  • Serious eye damage (H318)
  • Skin irritation (H315)
  • Respiratory irritation (H335)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.