Guaifenesin (INN)
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Guaifenesin (INN) is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.
Guaifenesin (3-(2-methoxyphenoxy)propane-1,2-diol, CAS 93-14-1) is a guaicol ether primarily used as an expectorant (FIFO) in oral medications. In cosmetics and personal care, it has been used in some topical formulations for its muscle-relaxant properties and to reduce the perception of skin irritation. The compound is not specifically restricted under EU Regulation (EC) No 1223/2009 Annexes II or III, indicating no major safety concerns at cosmetic use levels. Guaifenesin has FEMA GRAS status for food use and a history of safe pharmaceutical use, supporting its acceptability in cosmetics.
Skin benefits
- Muscle-relaxant properties in topical use
- Anti-irritant potential
Known concerns
- Primarily a pharmaceutical agent
- Limited cosmetic-specific safety data
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.