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Guaifenesin (INN)

CAS 93-14-1
78

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Guaifenesin (INN) is a cosmetic ingredient used in product formulation. Exercise caution due to limited available safety data.

Guaifenesin (3-(2-methoxyphenoxy)propane-1,2-diol, CAS 93-14-1) is a guaicol ether primarily used as an expectorant (FIFO) in oral medications. In cosmetics and personal care, it has been used in some topical formulations for its muscle-relaxant properties and to reduce the perception of skin irritation. The compound is not specifically restricted under EU Regulation (EC) No 1223/2009 Annexes II or III, indicating no major safety concerns at cosmetic use levels. Guaifenesin has FEMA GRAS status for food use and a history of safe pharmaceutical use, supporting its acceptability in cosmetics.

Skin benefits

  • Muscle-relaxant properties in topical use
  • Anti-irritant potential

Known concerns

  • Primarily a pharmaceutical agent
  • Limited cosmetic-specific safety data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.