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HUMAN ADIPOSE DERIVED MESENCHYMAL STEM CELL CONDITIONED MEDIA

50

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

The growth medium from cultured human fat-derived mesenchymal stem cells, containing well-documented MSC secretions with anti-inflammatory and regenerative properties.

Human adipose-derived MSC conditioned media is regulated under EU Annex II/416 for materials of human origin. Adipose-derived MSCs are among the most studied cell types in regenerative medicine, and their secretome is relatively well characterised, including VEGF, HGF, TGF-beta and IL-10. The human source eliminates TSE concerns, but pathogen screening and donor consent documentation are mandatory. It is one of the more compliant options among human cell media for EU cosmetic use.

Skin benefits

  • Well-characterised MSC secretome with anti-inflammatory properties
  • Contains HGF and VEGF with angiogenic effects
  • TGF-beta supports collagen synthesis
  • One of the better-studied conditioned media for skin applications

Known concerns

  • EU Annex II/416 restriction
  • Pathogen screening from surgical adipose tissue source required
  • FBS in culture medium compliance required
  • Batch variability from primary MSC culture

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.