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Biotech Ingredient

HUMAN CARDIOMYOCYTE INDUCED PLURIPOTENT CELL CONDITIONED MEDIA

35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Media conditioned by human iPS-derived cardiomyocytes. Serious regulatory and safety questions — generally not accepted as a cosmetic ingredient.

Human cardiomyocyte induced pluripotent stem cell conditioned media is the culture medium harvested from human iPS-derived heart-muscle cell lines. It contains secreted proteins, growth factors, exosomes, and extracellular vesicles. Using human-cell-derived materials in cosmetics raises significant regulatory concern: EU Regulation (EC) 1223/2009 restricts ingredients of human origin, and the FDA has issued warnings against cosmetic products containing human-cell-derived components (e.g., exosome products). Quality control for residual viruses, DNA, and donor screening is demanding. Biological activity claims for growth-factor content trespass into drug jurisdiction. No SCCS or CIR monograph exists. Score in the red tier reflecting regulatory, safety, and positioning concerns rather than acute toxicity.

Function

SKIN PROTECTING, SKIN CONDITIONING - HUMECTANT

Skin benefits

  • Complex peptide/growth factor content
  • Novel biotech proposition

Known concerns

  • Human-cell-derived — regulatory restrictions in EU and US
  • Residual biological contamination risk
  • No cosmetic safety dossier
  • Crosses line toward drug claims
  • Marketing overstates biology

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.