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Biotech Active

HUMAN DERMAL FIBROBLAST SPHEROID CONDITIONED MEDIA

55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Conditioned media from human fibroblast spheroids — a growth-factor-rich active with ambiguous regulatory status and human-origin concerns.

Human Dermal Fibroblast Spheroid Conditioned Media is the culture supernatant from 3D-cultured human skin fibroblast spheroids, harvested for its secretome: growth factors (FGF, VEGF, TGF-beta), cytokines, matrix proteins and potentially extracellular vesicles. Cosmetic positioning centers on skin-regeneration and conditioning claims. Regulatory reality is more complex: EU Cosmetics Regulation 1223/2009 Annex II prohibits ingredients of human origin (cells, tissues or products thereof), placing this material outside permitted EU cosmetics; US FDA scrutinizes growth-factor and exosome-type cosmetics closely and has issued warnings about unapproved biologic claims. Beyond regulatory questions, batch-to-batch variability, immunogenic potential, and chronic-exposure uncertainty warrant real caution. Consumer safety at cosmetic use levels is probably acceptable short-term, but the classification ambiguity is the driving concern.

Function

SKIN CONDITIONING - HUMECTANT, SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Growth-factor-rich conditioning signal
  • Potential barrier and ECM support

Known concerns

  • Human-origin ingredient — banned from EU cosmetics
  • FDA biologic-classification scrutiny
  • Compositional variability
  • Unknown chronic topical effect

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.