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HUMAN ENDOTHELIAL CELL CONDITIONED MEDIA

CAS -
45

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

The growth medium from cultured human blood vessel lining cells, containing secreted vascular factors used in advanced skincare formulations.

Human endothelial cell conditioned media is restricted under EU Annex II/416 as a material of human origin. Endothelial cells line blood vessels and secrete angiogenic factors, cytokines and extracellular matrix components. The full composition of the secretome is undefined, raising concerns about batch reproducibility and potential contamination. Use in EU-marketed cosmetics requires thorough safety documentation.

Skin benefits

  • Contains angiogenic factors that may support skin microcirculation
  • Vascular endothelial growth signals may aid skin repair

Known concerns

  • EU Annex II/416 restriction — requires full safety dossier
  • Undefined secretome composition
  • Potential blood-borne pathogen contamination
  • FB S in culture medium requires separate compliance assessment

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.