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HUMAN FIBROBLAST CONDITIONED MEDIA

CAS -
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Growth medium collected from cultured human skin cells, containing secreted proteins and growth factors that may support skin renewal.

Human fibroblast conditioned media is regulated under EU Annex II/416, which restricts the use of materials of human origin in cosmetics pending further safety evaluation. The media contains undefined secreted factors including cytokines, growth factors and extracellular matrix proteins. If fetal bovine serum is used in the culture process it must also comply with EU animal by-product regulations.

Skin benefits

  • May deliver growth factors supportive of collagen production
  • Contains cytokines that could modulate skin inflammation

Known concerns

  • EU Annex II/416 restriction — requires safety assessment
  • Undefined secretome composition creates variability
  • Potential viral or pathogen contamination from human source
  • FB S in culture media raises animal by-product concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.