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HUMAN KERATINOCYTE CONDITIONED MEDIA

CAS -
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

The growth medium from cultured human skin cells, containing secreted skin-signalling molecules that may influence skin renewal processes.

Human keratinocyte conditioned media falls under EU Annex II/416 restriction for materials of human origin, requiring a safety evaluation before use. The media contains undefined secreted factors including cytokines, antimicrobial peptides and growth factors. If FBS is used in the base culture medium, compliance with EU animal by-product regulations is also required.

Skin benefits

  • Contains keratinocyte-derived growth factors with potential anti-ageing effects
  • May support skin barrier homeostasis through secreted factors

Known concerns

  • EU Annex II/416 restriction — safety assessment required
  • Undefined secretome with potential batch variability
  • Viral contamination risk from human cell source
  • FBS in culture media raises animal by-product compliance issues

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.