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HUMAN UMBILICAL MESENCHYMAL CELL CONDITIONED MEDIA

46

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

The growth medium from cultured human umbilical cord mesenchymal stromal cells, containing MSC-secreted immunomodulatory and regenerative factors.

Human umbilical cord mesenchymal stem cell conditioned media is restricted under EU Annex II/416. Mesenchymal stem cells (MSCs) from Wharton's jelly secrete a well-characterised mix of growth factors, cytokines and extracellular vesicles. This ingredient is among the more scientifically documented conditioned media, though the undefined nature of the secretome still requires safety assessment. It does not require separate animal by-product compliance since the human source eliminates TSE concerns.

Skin benefits

  • MSC-secreted factors may modulate skin inflammation
  • Growth factors support tissue repair and collagen synthesis
  • Contains extracellular vesicles with potential anti-ageing activity

Known concerns

  • EU Annex II/416 restriction
  • Undefined secretome — batch-to-batch variability
  • Donor screening and pathogen testing required
  • Immunogenic potential of xenogeneic FBS components in culture media

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.