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HUMAN UMBILICAL WHARTON'S JELLY MESENCHYMAL STEM CELL CONDITIONED MEDIA

46

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

The growth medium from cultured mesenchymal stem cells isolated from human umbilical cord Wharton's jelly, one of the most ethically acceptable human MSC sources.

Human umbilical Wharton's jelly MSC conditioned media is restricted under EU Annex II/416 as a material of human origin. Wharton's jelly is the standard name for the mucoid connective tissue of the umbilical cord. MSCs from this source are extensively studied and the secretome is well characterised. The ingredient is sourced from birth tissue with maternal consent, making it one of the least ethically contentious human cell sources. Full EU compliance requires documented donor consent, pathogen screening and safety evaluation.

Skin benefits

  • Well-documented MSC secretome with anti-inflammatory properties
  • Contains TGF-beta, VEGF, HGF and immunomodulatory cytokines
  • Considered one of the most scientifically robust human cell media options

Known concerns

  • EU Annex II/416 restriction
  • Donor consent and pathogen screening required
  • FBS in culture medium raises animal by-product compliance
  • Batch variability from primary MSC culture

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.