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Hydrazides and their salts e.g. Isoniazid (INN)

CAS 54-85-3
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A cosmetic ingredient. Exercise caution due to limited available safety data.

Hydrazides and their salts, including isoniazid (CAS 54-85-3), are listed in EU Annex II at concentrations >=0.1%. The restriction reflects both the pharmacological activity of these compounds and the broader concern about antibiotic use in non-medicinal contexts, including the potential for antibiotic resistance development. Isoniazid itself is used as an antibiotic in human medicine, making its use in cosmetics entirely inappropriate from a regulatory perspective.

Known concerns

  • EU Annex II banned at >=0.1%
  • Antibiotic substance — resistance concern
  • Pharmacological activity of hydrazides

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.