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Skin Conditioning

HYDROLYZED HUMAN ADIPOSE STROMAL CELL CONDITIONED MEDIA

30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Hydrolysed conditioned medium from human fat-stromal cell cultures. Same human-tissue sourcing concerns as exosomes — restricted in the EU and a US regulatory grey area.

Hydrolyzed human adipose stromal cell conditioned media is the soluble fraction (growth factors, cytokines, peptides) collected from cultured human adipose-derived stromal cells, then enzymatically hydrolysed for cosmetic use. Like other human-cell-derived ingredients, it raises significant regulatory and safety questions: EU Regulation 1223/2009 effectively excludes human-derived materials from cosmetics under Annex II, and US FDA guidance suggests products marketed for therapeutic regeneration may be biologics rather than cosmetics. Donor screening, viral inactivation, sterility, and batch consistency are not standardised at industry scale. There is no SCCS or CIR opinion; efficacy claims are largely supplier-driven.

Function

SKIN CONDITIONING - EMOLLIENT

Skin benefits

  • Marketed as growth factor and cytokine source
  • Promoted for skin regeneration

Known concerns

  • EU Annex II concern over human-derived ingredients
  • Sterility, viral, and donor-screening risks
  • Regulatory grey area in US (potential FDA biologic)
  • No SCCS or CIR cosmetic safety opinion
  • Ethical sourcing concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.