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Hydroquinone methylether / Mequinol

CAS 150-76-5
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A skin-lightening agent restricted to 0.02% in EU cosmetics after mixing, due to potential for ochronosis and cytotoxicity at higher concentrations.

Hydroquinone methylether (p-methoxyphenol, mequinol) is listed in EU Annex III (restricted substances) with a maximum concentration of 0.02% in cosmetic products after mixing for use. The SCCS has raised concerns about ochronosis with prolonged use, cytotoxicity at higher concentrations, and potential endocrine-disrupting properties. H351 (suspected carcinogen) and H361 (reproductive toxicity) are classified.

Skin benefits

  • Skin lightening agent
  • Used in professional skincare for hyperpigmentation

Known concerns

  • EU Annex III restricted to 0.02% after mixing
  • Ochronosis risk with prolonged use
  • Cytotoxicity at higher concentrations
  • Suspected carcinogen (H351)
  • Reproductive toxicity concern (H361)

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.