mestranol
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A potent synthetic estrogen used in oral contraceptives, subject to pharmaceutical regulation and not authorized as a cosmetic ingredient.
Mestranol (3-methoxynorethisterone; 17-alpha-ethynylestradiol 3-methyl ether) is a potent synthetic estrogen historically used in oral contraceptives and hormone replacement therapy. It is not listed in EU CosIng as a cosmetic ingredient and is regulated as a drug substance. Its use in cosmetics would be considered prohibited or would require strict authorization under Annex III due to its potent estrogenic activity and associated risks including thromboembolism and cancer risk.
Known concerns
- Potent estrogenic activity — serious systemic health risks
- Prohibited or strictly restricted for cosmetic use in EU
- Drug substance classification — not a cosmetic ingredient
- Associated with thromboembolic and cancer risks
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.