Skip to content

Banned Substance

Methotrexate (INN)

CAS 59-05-2 Updated
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Methotrexate is a chemotherapy and immunosuppressant drug, also a powerful reproductive toxicant. Banned in EU cosmetics under Annex II.

Skin benefits

  • Pharmaceutical use in oncology, rheumatology, dermatology (psoriasis)

Known concerns

  • EU Annex II banned in cosmetics
  • Antineoplastic / immunosuppressant
  • Strong reproductive toxicant — abortifacient
  • Pharmaceutical-only substance

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Related banned substances

3
2-Methoxyethanol [1] and its acetate (2-Methoxyethyl acetate) [2]
Banned Substance
 3
Aniline, its salts and its halogenated and sulphonated derivatives
Banned Substance
 3
Apocynum cannabium L. and its preparations
Banned Substance
 3
DIETHYLENE GLYCOL
Banned Substance
 3
Daminozide
Banned Substance
 3
Dinoterb, its salts and esters
Banned Substance
 3
Dioxane
Banned Substance
 3
Diphtheria antitoxin
Banned Substance

Check your shelf

Find Methotrexate (INN) in your products.

Scan any cosmetic product with LuxSense to see if it contains Methotrexate (INN) and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.