Skip to content

NAPHAZOLINE HCL

CAS 550-99-2
22

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An imidazoline derivative with vasoconstrictive properties severely restricted in EU cosmetics due to systemic effects.

Naphazoline hydrochloride is an imidazoline derivative used as a decongestant in ophthalmic and nasal products. It carries an acute oral toxicity warning (H300: Fatal if swallowed) and is listed in EU Annex III (reference II/244) restricting its use in cosmetic products. Systemic absorption of naphazoline can cause serious cardiovascular effects including hypertension and bradycardia. These restrictions effectively prohibit cosmetic use of this ingredient.

Skin benefits

  • Vasoconstrictive (restricted medical use only)

Known concerns

  • EU Annex III restricted (II/244)
  • Acute oral toxicity (H300: Fatal if swallowed)
  • Cardiovascular effects from systemic absorption
  • Severe restrictions limit cosmetic use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

Check your shelf

Find NAPHAZOLINE HCL in your products.

Scan any cosmetic product with LuxSense to see if it contains NAPHAZOLINE HCL and get a full ingredient breakdown with safety scores.

This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.