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Neostigmine Methylsulfate

CAS 51-60-5
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Neostigmine Methylsulfate is a cosmetic ingredient. Exercise caution due to limited available safety data.

Neostigmine is a reversible acetylcholinesterase inhibitor used to treat myasthenia gravis and reverse neuromuscular blockade. It carries one of the most extensive hazard statement profiles with H300, H301, H310 (acute toxicity multiple routes), H315, H319, H330 (respiratory toxicity), H334 (respiratory sensitization), and H335. The narrow therapeutic window and life-threatening risks of cholinesterase inhibition preclude any cosmetic use.

Known concerns

  • Acetylcholinesterase inhibitor
  • Acute toxicity multiple routes (H300, H301, H310, H330)
  • Respiratory sensitization (H334)
  • Life-threatening effects possible
  • EU Annex II prohibited

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.