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Peptide / signaling

NICOTINOYL TRIPEPTIDE-1

CAS -
68

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A niacinamide-linked tripeptide used in anti-aging and brightening serums. Marketed for tone and barrier support, but independent clinical evidence remains limited and most data comes from suppliers.

Skin benefits

  • Vitamin B3 conjugated tripeptide marketed for skin barrier support
  • May help improve skin tone and reduce appearance of redness
  • Combines niacinamide-like activity with peptide signaling
  • Used at low concentrations in leave-on products

Known concerns

  • Limited independent clinical evidence outside supplier data
  • Long-term safety data sparse
  • Efficacy claims rely largely on in vitro studies

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.