Skin Conditioning
PALMITOYL TRIPEPTIDE-56
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A lipidated tripeptide — a short peptide anchored to palmitic acid for better skin penetration. Part of the widely used palmitoyl-peptide family.
Palmitoyl tripeptide-56 is a short synthetic peptide acylated with a 16-carbon palmitic acid chain. The lipid tail enhances compatibility with the stratum corneum, improving delivery of the peptide head. The palmitoyl-peptide family (including palmitoyl tripeptide-1 and -38, and palmitoyl pentapeptide-4) has decades of cosmetic use with a benign safety profile, though this specific numbered member lacks a dedicated CIR or SCCS review. Use levels are typically in the low ppm range and the molecule is well tolerated in leave-on products. Sensitive or acne-prone users occasionally report aggravation from heavily palmitoylated formulas.
Function
Skin benefits
- Enhanced skin penetration via lipid tail
- Peptide signalling activity
- Compatible with emulsion bases
Known concerns
- Supplier-sourced efficacy
- No monograph for this specific INCI
- Possible trigger for acne-prone users
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.