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Crosslinker / Biomaterial

PEG-444 PENTAERYTHRITYL TETRA(GLUTAROYLSUCCINIMIDE)

CAS -
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A high-molecular-weight PEG crosslinker with four activated NHS ester arms. Used mainly in medical hydrogels and sealants. The reactive groups make it a niche ingredient and not a standard cosmetic active.

Skin benefits

  • Activated PEG crosslinker used in hydrogel and biomedical materials
  • Can form covalent gels with amine-containing biomolecules
  • Used in tissue sealants and some advanced topical platforms

Known concerns

  • Very reactive NHS ester groups, can react with skin proteins
  • Limited use and review history in cosmetic products
  • High molecular weight reduces systemic risk but reactivity is the issue
  • Best confined to controlled medical-device formats

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Same plant / compound family

70
PEG-444 PENTAERYTHRITYL TETRA(AMIDOGLUTAROYL SUCCINIMIDO ETHYL ETHER)
Film Former

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.