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pipradrol

CAS 467-60-7
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A CNS stimulant with serious cardiovascular and psychiatric risks, entirely prohibited in cosmetic formulations under pharmaceutical regulations.

Pipradrol (CAS 467-60-7, also known as mertron; 2-(piperidin-2-yl)indane or related structure) is a central nervous system stimulant classified as a piperidine derivative with pharmacological activity similar to amphetamines. It acts as a norepinephrine-dopamine reuptake inhibitor and has been used historically as an analeptic and for ADHD treatment, though with significant side effect concerns. Under EU Regulation (EC) No 1223/2009, substances with pharmacological activity (CNS-active agents) are prohibited in cosmetic products. The compound presents serious risks including cardiovascular effects, insomnia, and addiction potential, making it wholly incompatible with cosmetic safety requirements.

Known concerns

  • CNS stimulant prohibited in cosmetics
  • Cardiovascular and psychiatric risks
  • No topical safety data
  • EU Regulation 1223/2009 Article 4 violation

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.