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QUININE

CAS 130-95-0
42

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Quinine from cinchona bark is restricted in EU rinse-off cosmetics to 0.5% due to serious cardiac and neurological toxicity risks at higher exposures.

Quinine (C20H24N2O2) is a cinchona alkaloid with well-documented pharmacological effects including cardiotoxicity (QT prolongation, ventricular arrhythmias), CNS effects (tinnitus, visual disturbances, headache), and hypersensitivity reactions. Under EU Regulation (EC) No 1223/2009 Annex III with reference III/21, quinine is restricted to 0.5% in rinse-off hair and body care products and prohibited in oral care products. These restrictions reflect the narrow margin between therapeutic and toxic doses. The ingredient is prohibited in products for children under 3 years in some member states.

Skin benefits

  • Traditional astringent
  • Bitter taste sensation (in rinse-off only)
  • Limited direct skin benefits

Known concerns

  • EU Annex III restricted to 0.5% in rinse-off products
  • Serious cardiac toxicity risk (QT prolongation, arrhythmias)
  • CNS toxicity at high doses
  • Photosensitization potential
  • Prohibited in oral care products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.