Conditioning Agent
RICE SH-OLIGOPEPTIDE-1
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A rice plant-produced version of human Epidermal Growth Factor (EGF) — promotes skin cell renewal for anti-aging. Plant-made for purity, but growth factor concerns apply.
Rice sh-Oligopeptide-1 is a recombinant human EGF (Epidermal Growth Factor) produced in rice (Oryza sativa) through molecular farming (transient expression or stable transgenesis). The 53-amino acid peptide is identical to human EGF and may contain disulfide bonds and/or glycosylation. Rice-based expression offers advantages including proper eukaryotic protein folding, absence of bacterial endotoxins, and potential for large-scale agricultural production. The same growth factor safety concerns apply as for other EGF variants — while anti-aging effects are demonstrated, the theoretical risk of promoting abnormal cell growth in predisposed individuals persists.
Function
Skin benefits
- Stimulates skin cell renewal and proliferation
- Anti-aging effects — fine line reduction
- Wound healing promotion
- Plant-produced — no bacterial endotoxin concerns
Known concerns
- Growth factors may theoretically promote tumor growth
- Long-term safety of topical growth factor use not established
- Novel biotechnology ingredient
- Same concerns as other recombinant EGF variants
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.