Secondary alkyl- and alkanolamines and their salts
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A cosmetic ingredient. Exercise caution due to limited available safety data.
Secondary alkanolamines such as diethanolamine (DEA, CAS 111-42-2) and diisopropanolamine (DIPA, CAS 110-97-4) are used in cosmetic formulations as emulsifying agents and pH adjusters. Their restriction stems primarily from the potential to form N-nitrosodiethanolamine (NDELA), a carcinogenic nitrosamine, particularly when in combination with nitrosating agents or nitrate-containing ingredients. The EU's general requirement to avoid nitrosamine formation restricts these substances in practice. Hazard statements include H302, H315, H318, H317, H373, H351, and H361.
Known concerns
- Nitrosamine formation potential (NDELA)
- H317 skin sensitisation
- H318 eye damage
- H351/H361 reproductive concerns
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.