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Spironolactone (INN)

CAS 52-01-7
3

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Spironolactone (inn) is a cosmetic ingredient. Raw material is classified as a suspected carcinogen. Exercise caution due to limited available safety data.

Spironolactone is listed in Annex II of EU Regulation (EC) No 1223/2009. As an endocrine-active pharmaceutical, it can affect androgen and aldosterone receptors systemically. While it has been used in dermatology for acne and hirsutism, cosmetic application of this drug substance is prohibited due to its hormonal mechanism of action and potential for systemic effects from topical exposure.

Known concerns

  • Prohibited in EU cosmetics (Annex II)
  • Endocrine-disrupting pharmaceutical
  • Antiandrogenic activity
  • Potential systemic hormonal effects from topical use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.