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Denaturant

SUCROSE OCTAACETATE

CAS 126-14-7
70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

An octa-acetylated sugar (one of the most bitter known) used as a denaturant to keep nail polishes and other products from being ingested.

Sucrose octaacetate (CAS 126-14-7) is a fully acetylated derivative of sucrose in which all eight hydroxyl groups are replaced with acetate esters. It is one of the bitterest substances known and is used as a bittering agent (denaturant) in products where accidental ingestion must be deterred — for example nail polishes, denatonium-style formulations, and alcohol denaturing. It has food-contact and pharmaceutical use precedent with FDA approval as an indirect food additive and approval as a denaturant under TTB regulations. In cosmetics it provides functional denaturation rather than skin benefits. Generally safe at used levels; eye irritation possible at higher concentrations. No GHS hazards at cosmetic use.

Function

DENATURANT, FRAGRANCE

Skin benefits

  • Used as a denaturant and flavor masking ingredient
  • Very bitter taste prevents product ingestion
  • Long food-contact safety precedent

Known concerns

  • Extreme bitterness means accidental transfer to lips is unpleasant
  • Limited skin-benefit functions
  • Can irritate eyes at higher levels

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.