TEPRENONE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Also known as Geranylgeranylacetone — an oral anti-ulcer medication being explored in topical skincare for its ability to induce heat shock proteins and support skin barrier function.
Teprenone (Geranylgeranylacetone, GGA) is a polyisoprenoid originally developed as an oral anti-ulcer drug (marketed in Japan). It is known to induce heat shock protein 70 (HSP70) expression, which plays a protective role against cellular stress. Topical application research is emerging but still limited. It is not a standard cosmetic ingredient and is not listed in EU CosIng or restricted Annexes, placing it in the 'novel/novel use' category.
Skin benefits
- May induce HSP70 for cellular stress protection
- Potential anti-aging and barrier-supporting properties (emerging research)
Known concerns
- Limited topical safety data
- Primarily an oral drug with unknown dermal absorption profile
- Novel cosmetic application with unconfirmed long-term safety
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.