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Banned Substance

Tetraethyl pyrophosphate (TEPP - ISO)

CAS 107-49-3
0

Safety score Β· 0–100

Not Rated

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

TEPP β€” one of the most acutely toxic organophosphates ever marketed. Fatal through skin absorption. Not remotely a cosmetic.

Tetraethyl pyrophosphate (TEPP, CAS 107-49-3) is one of the earliest organophosphate insecticides, developed in the 1930s-40s and notorious for its extreme acute toxicity. It is a potent irreversible inhibitor of acetylcholinesterase and is classified by the WHO as Class Ia β€” extremely hazardous. Lethal doses have been documented via dermal exposure alone. EU CLP classifies it as a Category 1 acute toxicant by oral, dermal, and inhalation routes (H300/H310/H330). It has been banned for agricultural use in the EU, US, and most countries for decades. EU Regulation (EC) No 1223/2009 Annex II prohibits it in cosmetic products. There is absolutely no cosmetic rationale.

Skin benefits

  • No legitimate cosmetic use β€” extremely acutely toxic insecticide

Known concerns

  • WHO Class Ia extremely hazardous
  • Fatal on skin contact (H310)
  • Acetylcholinesterase inhibitor
  • EU Annex II cosmetic ban
  • Banned from agriculture globally

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.