Banned Substance
Tetraethyl pyrophosphate (TEPP - ISO)
Safety score · 0–100
Not Rated
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
TEPP — one of the most acutely toxic organophosphates ever marketed. Fatal through skin absorption. Not remotely a cosmetic.
Tetraethyl pyrophosphate (TEPP, CAS 107-49-3) is one of the earliest organophosphate insecticides, developed in the 1930s-40s and notorious for its extreme acute toxicity. It is a potent irreversible inhibitor of acetylcholinesterase and is classified by the WHO as Class Ia — extremely hazardous. Lethal doses have been documented via dermal exposure alone. EU CLP classifies it as a Category 1 acute toxicant by oral, dermal, and inhalation routes (H300/H310/H330). It has been banned for agricultural use in the EU, US, and most countries for decades. EU Regulation (EC) No 1223/2009 Annex II prohibits it in cosmetic products. There is absolutely no cosmetic rationale.
Skin benefits
- No legitimate cosmetic use — extremely acutely toxic insecticide
Known concerns
- WHO Class Ia extremely hazardous
- Fatal on skin contact (H310)
- Acetylcholinesterase inhibitor
- EU Annex II cosmetic ban
- Banned from agriculture globally
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related banned substances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.