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Thiotepa (INN)

CAS 52-24-4
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Thiotepa (inn) is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Thiotepa (INN, CAS 52-24-4) is an ethyleneimine derivative used as an antineoplastic agent in pharmaceutical applications. In the EU Cosmetics Regulation (EC) No 1223/2009, Thiotepa is listed in Annex II (banned substances) as substance code 1374. This listing explicitly prohibits its use in cosmetic products. The substance is a known carcinogen and mutagen with severe systemic toxicity. Any presence of Thiotepa in a cosmetic product constitutes a violation of EU cosmetic regulations. This ingredient has no place in any cosmetic formulation regardless of concentration.

Known concerns

  • Explicitly banned in EU Annex II (code 1374)
  • Known carcinogen
  • Known mutagen
  • Severe systemic toxicity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.