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Skin Conditioning

THURFYL NICOTINATE

CAS 70-19-9
70

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Tetrahydrofurfuryl nicotinate — a skin-penetrating ester of niacin. Triggers a warming flush, so it is used in sports rubs, not in gentle skincare.

Thurfyl nicotinate (CAS 70-19-9), more correctly tetrahydrofurfuryl nicotinate, is an ester of niacin (vitamin B3) with tetrahydrofurfuryl alcohol. The ester form is strongly lipophilic and absorbs quickly through skin, where it releases niacin and causes marked cutaneous vasodilation. This creates a warming, tingling flush that is the goal in massage balms, warming liniments, and some antiperspirant formulations. It has a long pharmaceutical history (trafuril). Not classified as a carcinogen, mutagen, or reproductive toxin, but the flush reaction itself is intentional and can be uncomfortable — it is wholly inappropriate for rosacea-prone or easily irritated skin, and is generally avoided in leave-on facial products.

Skin benefits

  • Boosts surface blood flow — brings a visible flush
  • Used in warming rubs and sports/massage gels
  • Delivers niacin (vitamin B3) topically
  • Small use-percent is enough for effect

Known concerns

  • Causes vasodilation — temporary redness, warmth, stinging
  • Not suitable for rosacea-prone or sensitive skin
  • Care needed in leave-on facial products
  • Allergic reactions reported, though uncommon

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.