Banned (EU Annex II)
Trichlormethine (INN) and its salts
Safety score · 0–100
Not Rated
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Trichlormethine is a nitrogen-mustard chemotherapy/warfare agent — EU Annex II banned, IARC-carcinogen-class, never permitted in cosmetics.
Trichlormethine (CAS 555-77-1; hydrochloride 817-09-4; N-oxide 126-85-2; and related salts such as 6138-32-5) is tris(2-chloroethyl)amine, the original chemical-warfare nitrogen mustard and the parent of several chemotherapy alkylating agents (e.g., mechlorethamine). It covalently crosslinks DNA, causing vesication on skin and cytotoxic/myelosuppressive effects systemically. Nitrogen mustards as a class are IARC Group 1 human carcinogens. Trichlormethine is explicitly listed in the EU Cosmetics Regulation (EC) 1223/2009 Annex II as a substance prohibited in cosmetic products. Presence in a cosmetic ingredient database is a compliance red flag, not a cosmetic input. Score 0 reflects total prohibition and extreme hazard.
Skin benefits
- None — prohibited in cosmetics
Known concerns
- EU Annex II prohibited substance
- IARC Group 1-class carcinogen
- DNA alkylator — mutagenic and teratogenic
- Historic chemical warfare agent
- Vesicant — causes severe skin damage
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related banned (eu annex ii)s
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.