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Tripelennamine (INN)

CAS 91-81-6
38

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Tripelennamine (INN) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Tripelennamine (pyribenzamine) is an ethylenediamine-derivative antihistamine historically used orally and topically for allergic rhinitis and itching. While it is an INN-listed drug substance, it is not commonly used in contemporary cosmetic formulations. The ethylenediamine moiety is itself a known sensitizer, and tripelennamine has been associated with contact dermatitis in some individuals. EU CosIng does not list tripelennamine as an authorized cosmetic ingredient, suggesting it falls outside the normal safety assessment framework for topical use in cosmetics.

Skin benefits

  • H1 antihistamine activity may reduce histamine-mediated skin irritation
  • Historical use in anti-itch topical formulations

Known concerns

  • Known sensitizer — ethylenediamine backbone associated with allergic contact dermatitis
  • Not listed in EU CosIng — cosmetic authorization uncertain
  • Sedating antihistamine — CNS side effects possible with systemic absorption
  • Limited contemporary safety data for cosmetic topical use

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.